It was the second double-fatality accident in troop H in the last three days.
The Missouri State Highway Patrol identifies the victims as Nicole Browden, 30, and her husband, Michael Browden, 27.
A crash report indicates Nicole Browden lost control of the Hyundai she was driving along Missouri Route 31 north of Clarksdale at about 4am Monday.
The vehicle left the roadway, vaulted an embankment and rolled over before hitting another embankment.
On Friday night, a rollover wreck near Chillicothe killed Byron King, of Chillicothe and Dakota Nichols of Trenton. (Find details here)